Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease

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Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease.

AIMS The mechanisms responsible for renal injury in atherosclerotic renovascular disease (ARVD) are incompletely understood, and few therapeutic options are available to reverse it. We hypothesized that chronic renal damage involves mitochondrial injury, and that mitochondrial protection would reduce renal fibrosis and dysfunction in ARVD pigs. METHODS AND RESULTS Domestic pigs were studied a...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2014

ISSN: 1755-3245,0008-6363

DOI: 10.1093/cvr/cvu157